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Dr. Christina Schreck | Stammzell physiologie | Best Scholar Award

Dr. Christina Schreck is a researcher and clinician at the TUM University Hospital, Klinikum rechts der Isar, affiliated with the Technical University of Munich’s Department of Medicine III in Hematology/Oncology. Based in Germany, her work focuses on advancing cancer treatment, particularly in the areas of hematology and oncology. Dr. Schreck’s research interests include developing novel therapeutic approaches for blood-related cancers and improving patient outcomes through cutting-edge clinical practices and scientific innovations. She is part of a leading medical institution known for excellence in cancer research and care.

PROFILE

Orcid Profile

Educational Details

Dr. Christina Schreck completed her PhD (Dr. rer. nat.) in February 2015 at the Faculty of Medicine, Technical University of Munich (TUM), with her research conducted at the III. Medical Clinic for Hematology and Oncology at Klinikum rechts der Isar. She graduated magna cum laude for her work on hematopoiesis and leukemia. Prior to her PhD, she earned a Diploma in Biology from TUM in 2008, specializing in microbiology, with minors in virology and zoology, achieving a grade of 1.4.

Dr. Schreck has also pursued further education, obtaining FELASA Category C certification in laboratory animal science in 2010. From 2018 to 2020, she participated in the Keck Mentoring Program at TUM’s Faculty of Medicine, where she developed key soft skills in personality development, employee management, career planning, and time management through various seminars.

 Professional Experience : 

Dr. Christina Schreck has extensive experience in hematological research, currently serving as a Postdoctoral Fellow at Klinikum rechts der Isar, Technical University of Munich, since February 2015. She manages laboratory operations and oversees six sub-projects within the DFG Research Unit FOR 2033, focusing on hematopoietic niches. Her responsibilities include project planning, experiment design, data analysis, and manuscript preparation. Dr. Schreck regularly presents her findings at international conferences, such as those held in Madrid, Hamburg, and Vienna. She also lectures on ‘Experimental Hematology’ at TUM, supervises student projects, and actively contributes to grant writing for institutions like the German Research Foundation (DFG) and Deutsche Krebshilfe.

During her PhD research (2010-2015), Dr. Schreck explored the role of Wnt5a in hematopoiesis and leukemia at the Laboratory for Stem Cell Physiology at Klinikum rechts der Isar. Her work involved analyzing knockout animal models and employing techniques such as multi-color flow cytometry and immunofluorescence to study hematopoietic stem cells and the stromal microenvironment.

Research Focus

Dr. Christina Schreck’s research explores critical areas in hematology and oncology, focusing on the interactions between hematopoietic stem cells (HSCs) and their microenvironment during cellular stress. Her work investigates how these cells respond to stressors, such as radiation and chemotherapy, particularly the role of the small GTPase CDC42 in regenerating the bone marrow niche. Additionally, she examines the cytoskeleton of osteosarcoma cells and its influence on metastasis, offering insights into the mechanisms driving cancer spread and potential therapeutic targets for controlling metastatic progression.

Top Notable Publications

Landspersky T, Stein M, Saçma M, Geuder J, Braitsch K, Rivière J, Hettler F, Romero Marquez S, Vilne B, Hameister E, Richter D, Schoenhals E, Tuckermann J, Verbeek M, Herhaus P, Hecker JS, Bassermann F, Goetze KS, Enard W, Geiger H, Oostendorp RAJ, Schreck C. Targeting CDC42 reduces skeletal degeneration after hematopoietic stem cell transplantation. Blood Advances. 2024 Aug 19; bloodadvances.2024012879. doi: 10.1182/bloodadvances.2024012879.

Landspersky T, Saçma M, Rivière J, Hecker JS, Hettler F, Hameister E, Brandstetter K, Istvánffy R, Romero Marquez S, Ludwig R, Götz M, Buck M, Wolf M, Schiemann M, Ruland J, Strunk D, Shimamura A, Myers K, Yamaguchi TP, Kieslinger M, Leonhardt H, Bassermann F, Götze KS, Geiger H, Schreck C, Oostendorp RAJ. Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress. Blood. 2022 Feb 3; 139(5): 690-703. doi: 10.1182/blood.2021011775.

Hettler F, Schreck C, Romero Marquez S, Engleitner T, Vilne B, Landspersky T, Weidner H, Hausinger R, Mishra R, Oellinger R, Rauner M, Naumann R, Peschel C, Bassermann F, Rad R, Istvanffy R, Oostendorp RAJ. Osteoprogenitor SFRP1 prevents exhaustion of hematopoietic stem cells via PP2A-PR72/130-mediated regulation of p300. Haematologica. 2023 Feb 1; 108(2): 490-501. doi: 10.3324/haematol.2022.280760.

Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RAJ. Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. J Exp Med. 2017 Jan; 214(1): 165-181. doi: 10.1084/jem.20151414.

Florian MC, Nattamai KJ, Dörr K, Marka G, Uberle B, Vas V, Eckl C, Andrä I, Schiemann M, Oostendorp RA, Scharffetter-Kochanek K, Kestler HA, Zheng Y, Geiger H. A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature. 2013 Nov 21; 503(7476): 392-396. doi: 10.1038/nature12631.

Weickert MT, Hecker JS, Buck MC, Schreck C, Rivière J, Schiemann M, Schallmoser K, Bassermann F, Strunk D, Oostendorp RAJ, Götze KS. Bone marrow stromal cells from MDS and AML patients show increased adipogenic potential with reduced Delta-like-1 expression. Sci Rep. 2021 Mar 15; 11(1): 5944. doi: 10.1038/s41598-021-85122-8.

Ruf F, Schreck C, Wagner A, Grziwok S, Pagel C, Romero S, Kieslinger M, Shimono A, Peschel C, Götze KS, Istvanffy R, Oostendorp RAJ. Loss of Sfrp2 in the niche amplifies stress-induced cellular responses and impairs the in vivo regeneration of the hematopoietic stem cell pool. Stem Cells. 2016 Sep; 34(9): 2381-2392. doi: 10.1002/stem.2416.

Schreck C, Bock F, Grziwok S, Oostendorp RA, Istvánffy R. Regulation of hematopoiesis by activators and inhibitors of Wnt signaling from the niche. Ann N Y Acad Sci. 2014 Mar; 1310: 32-43. doi: 10.1111/nyas.12384.

Romero Marquez S, Hettler F, Hausinger R, Schreck C, Landspersky T, Henkel L, Angerpointner C, Demir IE, Schiemann M, Bassermann F, Götze KS, Istvánffy R, Oostendorp RAJ. Secreted factors from mouse embryonic fibroblasts maintain repopulating function of single cultured hematopoietic stem cells. Haematologica. 2021 Oct 1; 106(10): 2633-2640. doi: 10.3324/haematol.2020.249102.

Istvanffy R, Kröger M, Eckl C, Gitzelmann S, Vilne B, Bock F, Graf S, Schiemann M, Keller UB, Peschel C, Oostendorp RAJ. Stromal pleiotrophin regulates repopulation behavior of hematopoietic stem cells. Blood. 2011 Sep 8; 118(10): 2712-2722. doi: 10.1182/blood-2010-05-287235.

Scharler C, Poupardin R, Ebner-Peking P, Wolf M, Schreck C, Brachtl G, Cronemberger Andrade A, Krisch L, Daheron L, Schallmoser K, Jürchott K, Küchler J, Stachelscheid H, Volk HD, Oostendorp RAJ, Strunk D. Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2. Commun Biol. 2022 Nov 15; 5(1): 1246. doi: 10.1038/s42003-022-04078-1.

Christina Schreck | Stammzell physiologie | Best Scholar Award

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